- Hematology/Pediatric
-
Delta Neutrophil Index as a Prognostic Marker in the Pediatric Intensive Care Unit
-
In Suk Sol, Hyun Bin Park, Min Jung Kim, Seo Hee Yoon, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim
-
Korean J Crit Care Med. 2016;31(4):351-358. Published online November 30, 2016
-
DOI: https://doi.org/10.4266/kjccm.2016.00171
-
-
8,682
View
-
180
Download
-
4
Crossref
-
 Abstract
 PDF
- Background
The delta neutrophil index (DNI) is a useful marker for diagnosing and predicting the prognosis of sepsis. The purpose of this study was to investigate the usefulness of DNI as a prognostic marker in patients within the pediatric intensive care unit (PICU), as well as its association with other prognostic factors.
Methods
A total of 516 children admitted to Severance Children’s Hospital PICU from December 2009 to February 2015 were analyzed. DNI was measured on the day of PICU admission. Mortality was defined as death within 28 days following PICU admission.
Results
The median value of DNI was 1.2% (interquartile range [IQR] 0-4.3%) in the survivor group and 9.5% (IQR 2.3-20.8%) in the non-survivor group, and the difference was statistically significant (p < 0.001). DNI was significantly positively correlated with ICU scores such as Pediatric Index of Mortality 3 and Pediatric Risk of Mortality III, as well as with C-reactive protein and lactate levels. The area under the receiver operating characteristic curve of DNI for mortality was 0.748 (95% CI: 0.687-0.808) and the cut-off value was 4.95%.
Conclusions
The initial DNI level can be considered a useful indicator for predicting prognosis in PICU patients.
-
Citations
Citations to this article as recorded by  - Performance Comparison of Procalcitonin, Delta Neutrophil Index, C-Reactive Protein, and Serum Amyloid A Levels in Patients with Hematologic Diseases
Jooyoung Cho, Jong-Han Lee, Dong Hyun Lee, Juwon Kim, Young Uh
Diagnostics.2023; 13(7): 1213. CrossRef - Potential and promising marker for serious bacterial infections in children: Delta neutrophil index
Metin Yigit, Aslinur Ozkaya‐Parlakay, Naci Yilmaz, Ozhan Akyol, Belgin Gulhan, Saliha Kanik Yuksek, Basak Yalcin Burhan, Enes K Kilic, Cuneyt Karagol
Journal of Paediatrics and Child Health.2022; 58(9): 1623. CrossRef - Delta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsis
Nuriye Asli Melekoglu, Seyma Yasar, Mehmet Keskin
Journal of Pediatric Infectious Diseases.2021; 16(03): 099. CrossRef - Prognostic value of the delta neutrophil index in pediatric cardiac arrest
Seo Hee Yoon, Eun Ju Lee, Jinae Lee, Moon Kyu Kim, Jong Gyun Ahn
Scientific Reports.2020;[Epub] CrossRef
|
KSCCM
